Solubility study also indicated that FK has poor aqueous solubility and was independent of pH of the medium. Statistical analysis The effects of independent variables on the experimental response were modeled using a second order polynomial equation with a backward, stepwise linear regression technique. More importantly the large quantity of surfactants in the formulations can induce GI irritations. The improved therapeutic efficacy could be primarily because of increased solubility and dissolution rate of FK leading to its rapid and efficient dispersion in GI tract. Recently the liquid nanoemulsifying drug delivery systems SNEDDS have shown dramatic effects on improving oral bioavailability of poorly soluble drugs. Then the rotated SE pellets were sieved by mesh 60 sieve and weighed in order to determine friability.

Based on previous studies, 18 a self-emulsifying system was prepared containing a fixed proportion of loratadin 0. In contrast, Carbitol and propylene glycol, short chain amphiphiles, can penetrate perfectly at interface. Details of shape analysis results are brought in Table 3. Drug and excipients Sr. The pellets were produced by the following processes:

Effect of FK loading on physical stability of microemulsions was studied using optimized composition i.

Design and Evaluation of Self-Microemulsifying Drug Delivery System (SMEDDS) of Tacrolimus

Carbitol and propylene glycol, hydrophilic cosurfactants increased spontaneity of microemulsion formation. In this study, we intended to prepare and characterize solid self-nanoemulsifying drug delivery system for oral delivery of loratadin as the model insoluble drug.


This result could be related thexis the smaller droplet size of F The presentation is successfully added In Your Favorites.

solid smedds thesis

Microemulsion formulation for enhanced absorption of poorly soluble drugs I. Pharmacodynamic Evaluation In Mice Immunosuppressant effect of FK is due to its selective and reversible inhibition of T lymophocytes, preventing formation of interleukins that are responsible for T-cell activation and proliferation.

Quality assessment of the produced pellets was made by evaluating their size and shape, 22 and percentages of the SE pellets in the sieve fraction are shown in Table 3. Preparation and evaluation of the self-emulsifying drug delivery system containing loratadine.

National Center for Biotechnology InformationU. Freshly prepared double distilled water was used. The experiments were carried out in triplicates and reported as mean droplet size and thdsis dispersity index PDI. Oil and surfactant were accurately weighed in to glass vial.


Thus, the study gave an insight into relative emulsification properties of SMEDDS components and forms the basis of their selection. Mice were administered formulations equivalent to 3. Improved oral bioavailability of artemisinin through inclusion complexation with beta- and gamma-cyclodextrins. Optimum SNE pellet formulations were then selected and their in-vitro drug release was evaluated in comparison with liquid SEDDS, conventional loratadin tablets and pellets. Oral delivery of liposomal tacrolimus: The resulting SNE pellets exhibited uniform size and shape.

Oral bioavailability of silymarin phytocomplex formulated as self-emulsifying pellets. Development of self-microemulsifying drug delivery systems SMEDDS for oral bioavailability enhancement of simvastatin in beagle dogs.


Analytical smedfs used for calibration: Journal List Adv Pharm Bull v. DisouzaPrincipalTatyasaheb kore college of Pharmacy, Warananagar.

solid smedds thesis

A small amount of oil in 0. In vitro dissolution test Smmedds vitro dissolution profile of different pellets formulations are shown in Figure 3.

Adv Drug Deliver Rev. Sirolimus solid self-microemulsifying pellets: Tacrolimus in solid organ transplantation: Hosmani Professor in Pharmaceutics Co-guided by: Presentation Description This presentation was made in Office Sodium crosscarmelose was provided by Fluka, Germany and lactose was purchased from Akbarieh pharmaceutical Co Iran. Merck, Darmstadt, Germany smedes as stationary phase.

Design and Evaluation of Self-Microemulsifying Drug Delivery System (SMEDDS) of Tacrolimus

Thus, it was thought that, combination of above factors smeedds result in an increase in rate and extent of absorption of FK leading to its improved therapeutic efficacy over commercial formulation.

Table 2 Compositions of the SNE pellets. Author information Article notes Copyright and License information Disclaimer. Moreover, the emulsion droplets lead to a faster and more uniform distribution of drug in the GI tract.